› 4awi

X-ray diffraction
1.91Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 8 Chain: A
Molecule details ›
Chain: A
Length: 369 amino acids
Theoretical weight: 42.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45983 (Residues: 1-364; Coverage: 85%)
Gene names: JNK1, MAPK8, PRKM8, SAPK1, SAPK1C
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand AQ2 1 x AQ2
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: P212121
Unit cell:
a: 50.438Å b: 72.747Å c: 110.155Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.219
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Crystal structures of ASK1-inhibtor complexes provide a platform for structure-based drug design.
Singh et al. (2013)
2 more

8 mentions without citation

The azaindole framework in the design of kinase inhibitors.
Mérour et al. (2014)
7 more