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X-ray diffraction
2.95Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117222 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Microphthalmia-associated transcription factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 118 amino acids
Theoretical weight: 14.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q08874 (Residues: 287-403; Coverage: 22%)
Gene names: Bw, Mi, Mitf, Vit
Sequence domains: Helix-loop-helix DNA-binding domain
Structure domains: Helix-loop-helix DNA-binding domain
5'-D(*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*T)-3' Chains: C, D
Molecule details ›
Chains: C, D
Length: 16 nucleotides
Theoretical weight: 4.9 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 151.42Å b: 45.09Å c: 110.66Å
α: 90° β: 136.47° γ: 90°
R-values:
R R work R free
0.255 0.253 0.274
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

21 review citations

TFEB at a glance.
Napolitano et al. (2016)
20 more

6 mentions without citation

Restricted leucine zipper dimerization and specificity of DNA recognition of the melanocyte master regulator MITF.
Pogenberg et al. (2012)
5 more