Function and Biology Details
Reaction catalysed:
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133817 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Angiotensin-converting enzyme, soluble form
Molecule details ›
Chain: A
Length: 589 amino acids
Theoretical weight: 68.07 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains: Angiotensin-converting enzyme
Length: 589 amino acids
Theoretical weight: 68.07 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P12821 (Residues: 642-1230; Coverage: 46%)
Sequence domains: Angiotensin-converting enzyme
Bradykinin-potentiating peptide B
Molecule details ›
Chain: P
Length: 11 amino acids
Theoretical weight: 1.18 KDa
Source organism: Gloydius blomhoffii
Expression system: Not provided
UniProt:
Length: 11 amino acids
Theoretical weight: 1.18 KDa
Source organism: Gloydius blomhoffii
Expression system: Not provided
UniProt:
- Canonical: P01021 (Residues: 103-113; Coverage: 5%)
