4ah2 Summary

pdbe.org/4ah2
spacer

HLA-DR1 with covalently linked CLIP106-120 in canonical orientation

The structure was published by Schlundt, A., Gunther, S., Sticht, J., et al., Roske, Y., Heinemann, U., and Freund, C., in 2012 in a paper entitled "Peptide Linkage to the Alpha-Subunit of Mhcii Creates a Stably Inverted Antigen Presentation Complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.36 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN and HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN\,DRB1-1 BETA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN P01903 (26-217) (DRA_HUMAN)search Homo sapienssearch < 90% 193 91%
B HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN\,DRB1-1 BETA CHAIN P04229 (30-227) (2B11_HUMAN)search ,
P04233 (106-120) (HG2A_HUMAN)search
Homo sapienssearch ,
Homo sapienssearch
< 90% ,
< 90%
229 86%


Chain Sequence family (Pfam)
A Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B CLIP, MHC2 interactingsearch, Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch

Chain ID Biological process (GO) Cellular component (GO)
A (P01903) immune responsesearch antigen processing and presentationsearch MHC class II protein complexsearch membranesearch
B (P04233P04229) antigen processing and presentationsearch immune responsesearch membranesearch MHC class II protein complexsearch

Chain InterPro annotation
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch