4aen Summary

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HLA-DR1 with covalently linked CLIP106-120 in reversed orientation

The structure was published by Schlundt, A., Gunther, S., Sticht, J., et al., Roske, Y., Heinemann, U., and Freund, C., in 2012 in a paper entitled "Peptide Linkage to the Alpha-Subunit of Mhcii Creates a Stably Inverted Antigen Presentation Complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1-1 BETA CHAIN, and HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN P01903 (26-217) (DRA_HUMAN)search Homo sapienssearch < 90% 207 85%
B HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1-1 BETA CHAIN P04229 (30-227) (2B11_HUMAN)search Homo sapienssearch < 90% 199 90%
C HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN P04233 (106-120) (HG2A_HUMAN)search Homo sapienssearch < 90% 16 93%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (26 - 217) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN Homo sapiens
P04229 (30 - 227) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1-1 BETA CHAIN Homo sapiens
P04233 (106 - 120) HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN Homo sapiens

Chain Sequence family (Pfam)
A Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C CLIP, MHC2 interactingsearch

Chain ID Cellular component (GO) Biological process (GO)
A (P01903) MHC class II protein complexsearch membranesearch immune responsesearch antigen processing and presentationsearch
B (P04229) membranesearch MHC class II protein complexsearch immune responsesearch antigen processing and presentationsearch

Chain InterPro annotation
A MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C