› 4zk3

X-ray diffraction
2Å resolution

Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. Low pH structure

Released:
DOI: 10.2210/pdb4zk3/pdb
PDB entry 4zk3 coloured by chain, front view.
PDB entry 4zk3 coloured by chain, side view.
PDB entry 4zk3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates.
Lysvand H, Helland R, Hagen L, Slupphaug G, Iversen OJ
Biochem Biophys Rep 2 132-136 (2015)
PMID: 29124154

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151529 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serpin B3 Chain: A
Molecule details ›
Chain: A
Length: 390 amino acids
Theoretical weight: 44.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29508 (Residues: 1-390; Coverage: 100%)
Gene names: SCCA, SCCA1, SERPINB3
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 53.161Å b: 68.843Å c: 104.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.181 0.244
Expression system: Escherichia coli BL21(DE3)

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Citations

2 review citations

Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics.
Chaves-Moreira et al. (2019)
1 more

1 mention without citation

Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates.
Lysvand et al. (2015)