› 4zk0

X-ray diffraction
2.15Å resolution

Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. High pH structure

Released:
DOI: 10.2210/pdb4zk0/pdb
PDB entry 4zk0 coloured by chain, front view.
PDB entry 4zk0 coloured by chain, side view.
PDB entry 4zk0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates.
Lysvand H, Helland R, Hagen L, Slupphaug G, Iversen OJ
Biochem Biophys Rep 2 132-136 (2015)
PMID: 29124154

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151529 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serpin B3 Chain: A
Molecule details ›
Chain: A
Length: 390 amino acids
Theoretical weight: 44.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29508 (Residues: 1-390; Coverage: 100%)
Gene names: SCCA, SCCA1, SERPINB3
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 50.808Å b: 68.273Å c: 105.773Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.174 0.234
Expression system: Escherichia coli BL21(DE3)

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Citations

2 review citations

Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics.
Chaves-Moreira et al. (2019)
1 more

3 mentions without citation

Integrated structural and evolutionary analysis reveals common mechanisms underlying adaptive evolution in mammals.
Slodkowicz et al. (2020)
2 more