› 4zgg

X-ray diffraction
1.23Å resolution

Crystal structure of a DJ-1 (PARK7) from Homo sapiens at 1.23 A resolution

Released:
DOI: 10.2210/pdb4zgg/pdb
PDB entry 4zgg coloured by chain, front view.
PDB entry 4zgg coloured by chain, side view.
PDB entry 4zgg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Joint Center for Structural Genomics (JCSG), Partnership for Nuclear Receptor Signaling Code Biology (NHRS), Partnership for T-Cell Biology (TCELL)

Function and Biology Details

Reaction catalysed: 
An N(6)-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H(2)O = a [protein]-L-lysine + lactate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-189205 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Parkinson disease protein 7 Chain: A
Molecule details ›
Chain: A
Length: 190 amino acids
Theoretical weight: 20.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99497 (Residues: 1-189; Coverage: 100%)
Gene name: PARK7
Sequence domains: DJ-1/PfpI family
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand EDO 10 x EDO
1 modified residue:
Ligand MSE 5 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL14-1
Spacegroup: P3121
Unit cell:
a: 75.002Å b: 75.002Å c: 74.897Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.117 0.116 0.134
Expression system: Escherichia coli

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