› 4zeq

X-ray diffraction
1.8Å resolution

Crystal Structure of human BFL-1 in complex with tBid BH3 peptide, Northeast Structural Genomics Consortium Target HX9247

Released:
DOI: 10.2210/pdb4zeq/pdb
PDB entry 4zeq coloured by chain, front view.
PDB entry 4zeq coloured by chain, side view.
PDB entry 4zeq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Guan R, Xiao R, Mao L, Montelione GT, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157367 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-related protein A1 Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 18.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16548 (Residues: 1-151; Coverage: 86%)
Gene names: BCL2A1, BCL2L5, BFL1, GRS, HBPA1
Sequence domains: Apoptosis regulator proteins, Bcl-2 family
Structure domains: Blc2-like
BH3-interacting domain death agonist p11 Chain: B
Molecule details ›
Chain: B
Length: 26 amino acids
Theoretical weight: 2.89 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P55957 (Residues: 79-104; Coverage: 13%)
Gene name: BID

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 43.339Å b: 43.469Å c: 46.263Å
α: 90° β: 114.21° γ: 90°
R-values:
R R work R free
0.198 0.196 0.239
Expression systems:
  • Escherichia coli
  • Not provided

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