PDB 4z7q structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Biochemical function:

not assigned

Biological process:

cell adhesion

Cellular component:

integrin complex

Sequence domains:

10 more domains

Structure analysis Details

Assemblies composition:

hetero hexamer (preferred)
hetero tetramer

Assembly name:

Integrin alphaIIb-beta3 complex and antibody and peptide (preferred)

PDBe Complex ID:

PDB-CPX-209194 (preferred)

Entry contents:

5 distinct polypeptide molecules

Macromolecules (8 distinct):

Integrin alpha-IIb heavy chain Chains: A, C

Molecule details ›

Chains: A, C
Length: 454 amino acids
Theoretical weight: 49.23 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:

Canonical: P08514 (Residues: 32-485; Coverage: 45%)

Gene names: GP2B, ITGA2B, ITGAB
Sequence domains: FG-GAP repeat
Structure domains: Integrin alpha, N-terminal

Integrin beta-3 Chains: B, D

Molecule details ›

Chains: B, D
Length: 471 amino acids
Theoretical weight: 51.96 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:

Canonical: P05106 (Residues: 27-497; Coverage: 62%)

Gene names: GP3A, ITGB3
Sequence domains:

Structure domains:

Monoclonal antibody 10E5 heavy chain Chains: E, H

Molecule details ›

Chains: E, H
Length: 219 amino acids
Theoretical weight: 23.61 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus

Structure domains: Immunoglobulins

Monoclonal antibody 10E5 light chain Chains: F, L

Molecule details ›

Chains: F, L
Length: 214 amino acids
Theoretical weight: 23.33 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus

Structure domains: Immunoglobulins

Tetrapeptide AGDV-NH2 Chains: G, I

Molecule details ›

Chains: G, I
Length: 5 amino acids
Theoretical weight: 358 Da
Source organism: Homo sapiens
Expression system: Not provided