› 4z0r

X-ray diffraction
1.75Å resolution

Crystal Structure of the CW domain of ZCWPW2 mutant F78R in complex with histone H3 peptide

Released:
DOI: 10.2210/pdb4z0r/pdb
PDB entry 4z0r coloured by chain, front view.
PDB entry 4z0r coloured by chain, side view.
PDB entry 4z0r coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Liu Y, Tempel W, Bountra C, Arrowsmith CH, Edwards AM, Min J, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159411 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Zinc finger CW-type PWWP domain protein 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 59 amino acids
Theoretical weight: 7.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q504Y3 (Residues: 21-78; Coverage: 16%)
Gene name: ZCWPW2
Sequence domains: CW-type Zinc Finger
Structure domains: Herpes Virus-1
Histone H3.1 Chain: D
Molecule details ›
Chain: D
Length: 16 amino acids
Theoretical weight: 1.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 2-16; Coverage: 11%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

4 bound ligands:
Ligand ZN 3 x ZN
Ligand SO4 1 x SO4
Ligand UNX 24 x UNX
Ligand EDO 1 x EDO
1 modified residue:
Ligand M3L 1 x M3L

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: R3
Unit cell:
a: 126.659Å b: 126.659Å c: 63.271Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.178 0.177 0.192
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

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