› 4z02

X-ray diffraction
1.87Å resolution

Crystal structure of BRD1 in complex with Isoquinoline-3-carboxylic acid

Released:
DOI: 10.2210/pdb4z02/pdb
PDB entry 4z02 coloured by chain, front view.
PDB entry 4z02 coloured by chain, side view.
PDB entry 4z02 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: DONG A, IQBAL A, WALKER JR, Bountra C, Arrowsmith CH, Edwards AM, BROWN PJ, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131987 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95696 (Residues: 925-1049; Coverage: 12%)
Gene names: BRD1, BRL, BRPF2
Sequence domains: PWWP domain
Structure domains: SH3 type barrels.

Ligands and Environments

3 bound ligands:
Ligand 4K8 2 x 4K8
Ligand EDO 1 x EDO
Ligand UNX 10 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 45.892Å b: 44.98Å c: 131.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.228 0.257
Expression system: Escherichia coli BL21(DE3)

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