› 4yr6

X-ray diffraction
2.38Å resolution

Fab fragment of 5G6 in complex with epitope peptide

Released:
DOI: 10.2210/pdb4yr6/pdb
PDB entry 4yr6 coloured by chain, front view.
PDB entry 4yr6 coloured by chain, side view.
PDB entry 4yr6 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody.
Tao Y, Zhang X, Liang X, Zang J, Mo X, Li R
Sci Rep 6 24789 (2016)
PMID: 27102061

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-235035 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
heavy chain of 5G6 Chains: A, D
Molecule details ›
Chains: A, D
Length: 221 amino acids
Theoretical weight: 23.56 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
light chain of 5G6 Chains: B, E
Molecule details ›
Chains: B, E
Length: 214 amino acids
Theoretical weight: 23.69 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Glycocalicin Chains: C, F
Molecule details ›
Chains: C, F
Length: 11 amino acids
Theoretical weight: 1.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P07359 (Residues: 503-512; Coverage: 2%)
Gene name: GP1BA

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 101.9Å b: 147.06Å c: 194.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.251
Expression system: Not provided

Quick links

Citations

2 review citations

Mechanisms of platelet clearance and translation to improve platelet storage.
Quach et al. (2018)
1 more