4yiq

X-ray diffraction
1.85Å resolution

Structure of the CEACAM6-CEACAM8 heterodimer

Released:
Source organism: Homo sapiens
Primary publication:
Diverse oligomeric states of CEACAM IgV domains.
Proc Natl Acad Sci U S A 112 13561-6 (2015)
PMID: 26483485

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-152187 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Carcinoembryonic antigen-related cell adhesion molecule 8 Chains: A, C
Molecule details ›
Chains: A, C
Length: 108 amino acids
Theoretical weight: 12.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31997 (Residues: 34-141; Coverage: 34%)
Gene names: CEACAM8, CGM6
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Carcinoembryonic antigen-related cell adhesion molecule 6 Chains: B, D
Molecule details ›
Chains: B, D
Length: 108 amino acids
Theoretical weight: 11.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P40199 (Residues: 34-141; Coverage: 35%)
Gene names: CEACAM6, NCA
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 62.465Å b: 97.192Å c: 97.691Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.186 0.213
Expression system: Escherichia coli BL21(DE3)