› 4x7q

X-ray diffraction
2.33Å resolution

PIM2 kinase in complex with Compound 1s

Released:
DOI: 10.2210/pdb4x7q/pdb
PDB entry 4x7q coloured by chain, front view.
PDB entry 4x7q coloured by chain, side view.
PDB entry 4x7q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-based design of low-nanomolar PIM kinase inhibitors.
Ishchenko A, Zhang L, Le Brazidec JY, Fan J, Chong JH, Hingway A, Raditsis A, Singh L, Elenbaas B, Hong VS, Marcotte D, Silvian L, Enyedy I, Chao J
Bioorg Med Chem Lett 25 474-80 (2015)
PMID: 25575657

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192818 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 312 amino acids
Theoretical weight: 34.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P1W9 (Residues: 1-311; Coverage: 100%)
Gene name: PIM2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 3YR 2 x 3YR
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: R3
Unit cell:
a: 142.265Å b: 142.265Å c: 61.75Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.196 0.258
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Pim Kinases: Important Regulators of Cardiovascular Disease.
Nock et al. (2023)
6 other articles

6 mentions without citation

Insights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors PIM447 and AZD1208: A Molecular Dynamics Simulation and MM/GBSA Calculation Study.
Chen et al. (2019)
5 more