› 4wz4

X-ray diffraction
1.05Å resolution

Function and Biology Details

Reaction catalysed: 
A beta-lactam + H(2)O = a substituted beta-amino acid
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150279 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-lactamase Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 39.5 KDa
Source organism: Pseudomonas aeruginosa PAO1
Expression system: Pseudomonas aeruginosa PAO1
UniProt:
  • Canonical: P24735 (Residues: 29-388; Coverage: 97%)
Gene names: PA4110, ampC
Sequence domains: Beta-lactamase
Structure domains: DD-peptidase/beta-lactamase superfamily

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand 3VU 1 x 3VU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 44.73Å b: 71.27Å c: 107.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.199
Expression system: Pseudomonas aeruginosa PAO1

Quick links

Citations

5 review citations

Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications.
Silva et al. (2020)
4 more

1 mention without citation

Targeting Antibiotic Resistance.
Chellat et al. (2016)