› 4wo8

X-ray diffraction
2.2Å resolution

The substrate-free duplicated taurocyamine kinase from Schistosoma mansoni

Released:
DOI: 10.2210/pdb4wo8/pdb
PDB entry 4wo8 coloured by chain, front view.
PDB entry 4wo8 coloured by chain, side view.
PDB entry 4wo8 coloured by chain, top view.
Source organism: Schistosoma mansoni
Primary publication:
The substrate-free and -bound crystal structures of the duplicated taurocyamine kinase from the human parasite Schistosoma mansoni.
Merceron R, Awama AM, Montserret R, Marcillat O, Gouet P
J Biol Chem 290 12951-63 (2015)
PMID: 25837252

Function and Biology Details

Reaction catalysed: 
ATP + taurocyamine = ADP + N-phosphotaurocyamine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147784 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Taurocyamine kinase Chain: A
Molecule details ›
Chain: A
Length: 716 amino acids
Theoretical weight: 80.42 KDa
Source organism: Schistosoma mansoni
Expression system: Escherichia coli
UniProt:
  • Canonical: P16641 (Residues: 31-746; Coverage: 96%)
Gene name: Smp_194770
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 52.84Å b: 122.02Å c: 62.97Å
α: 90° β: 108.1° γ: 90°
R-values:
R R work R free
0.179 0.176 0.224
Expression system: Escherichia coli

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Citations

1 review citation

Natural Products Containing 'Rare' Organophosphorus Functional Groups.
Petkowski et al. (2019)
2 other articles

1 mention without citation

The substrate-free and -bound crystal structures of the duplicated taurocyamine kinase from the human parasite Schistosoma mansoni.
Merceron et al. (2015)