› 4u82

X-ray diffraction
1.66Å resolution

Structure of S. aureus undecaprenyl diphosphate synthase in complex with FSPP and sulfate

Released:
DOI: 10.2210/pdb4u82/pdb
PDB entry 4u82 coloured by chain, front view.
PDB entry 4u82 coloured by chain, side view.
PDB entry 4u82 coloured by chain, top view.
Source organism: Staphylococcus aureus subsp. aureus N315
Primary publication:
Antibacterial drug leads: DNA and enzyme multitargeting.
Zhu W, Wang Y, Li K, Gao J, Huang CH, Chen CC, Ko TP, Zhang Y, Guo RT, Oldfield E
J Med Chem 58 1215-27 (2015)
PMID: 25574764

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-158015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Isoprenyl transferase Chain: A
Molecule details ›
Chain: A
Length: 256 amino acids
Theoretical weight: 29.9 KDa
Source organism: Staphylococcus aureus subsp. aureus N315
Expression system: Escherichia coli
UniProt:
  • Canonical: P60477 (Residues: 1-256; Coverage: 100%)
Gene names: SA1103, uppS
Sequence domains: Putative undecaprenyl diphosphate synthase
Structure domains: Decaprenyl diphosphate synthase-like

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand FPS 1 x FPS
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P41212
Unit cell:
a: 57.079Å b: 57.079Å c: 158.618Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.187 0.22
Expression system: Escherichia coli

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Citations

14 citation in other articles

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.
Stokes et al. (2017)
13 more

2 mentions without citation

Antibacterial drug leads: DNA and enzyme multitargeting.
Zhu et al. (2015)
1 more