› 4u40

X-ray diffraction
2.3Å resolution

Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) Bound to AMPPNP

Released:
DOI: 10.2210/pdb4u40/pdb
PDB entry 4u40 coloured by chain, front view.
PDB entry 4u40 coloured by chain, side view.
PDB entry 4u40 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Harris SF, Wu P, Coons M

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132055 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase kinase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 332 amino acids
Theoretical weight: 37.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O95819 (Residues: 2-328; Coverage: 26%)
Gene names: HGK, KIAA0687, MAP4K4, NIK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ANP 1 x ANP
Ligand MG 3 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 80.339Å b: 87.595Å c: 91.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.198 0.262
Expression system: Spodoptera frugiperda

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