Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Coagulation factor XIa complex (preferred)
PDBe Complex ID:
PDB-CPX-137279 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Coagulation factor XIa light chain
Molecule details ›
Chain: A
Length: 244 amino acids
Theoretical weight: 27.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 244 amino acids
Theoretical weight: 27.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P03951 (Residues: 388-625; Coverage: 39%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Coagulation factor XIa heavy chain
Molecule details ›
Chain: H
Length: 18 amino acids
Theoretical weight: 2.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Length: 18 amino acids
Theoretical weight: 2.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P03951 (Residues: 375-387; Coverage: 2%)
