› 4twk

X-ray diffraction
2.6Å resolution

Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)

Released:
DOI: 10.2210/pdb4twk/pdb
PDB entry 4twk coloured by chain, front view.
PDB entry 4twk coloured by chain, side view.
PDB entry 4twk coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Pike ACW, Dong YY, Tessitore A, Goubin S, Strain-Damerell C, Mukhopadhyay S, Kupinska K, Wang D, Chalk R, Berridge G, Grieben M, Shrestha L, Ang JH, Mackenzie A, Quigley A, Bushell SR, Shintre CA, Faust B, Chu A, Dong L, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Burgess-Brown NA, Carpenter EP

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131815 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel subfamily K member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 283 amino acids
Theoretical weight: 31.23 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O95069 (Residues: 41-315; Coverage: 65%)
Gene names: KCNK2, TREK, TREK1
Sequence domains: Ion channel
Structure domains: Helix Hairpins

Ligands and Environments

4 bound ligands:
Ligand K 3 x K
Ligand 37X 5 x 37X
Ligand MG 1 x MG
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 74.47Å b: 105.975Å c: 128.27Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.231 0.258
Expression system: Spodoptera frugiperda

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