› 4tuh

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170525 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2-like protein 1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 158 amino acids
Theoretical weight: 17.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07817 (Residues: 1-209; Coverage: 66%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand 38H 8 x 38H
Ligand EDO 14 x EDO
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21
Unit cell:
a: 59.834Å b: 109.661Å c: 102.099Å
α: 90° β: 91.77° γ: 90°
R-values:
R R work R free
0.174 0.172 0.209
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Targeting apoptosis in cancer therapy.
Carneiro et al. (2020)
9 more

4 mentions without citation

The Structural Biology of Bcl-xL.
Lee et al. (2019)
3 more