› 4rta

X-ray diffraction
2.12Å resolution

Cystal structure of the Dpy30 for MLL/SET1 COMPASS H3K4 trimethylation

Released:
DOI: 10.2210/pdb4rta/pdb
PDB entry 4rta coloured by chain, front view.
PDB entry 4rta coloured by chain, side view.
PDB entry 4rta coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation.
Zhang H, Li M, Gao Y, Jia C, Pan X, Cao P, Zhao X, Zhang J, Chang W
Protein Cell 6 147-51 (2015)
PMID: 25542209

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189880 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein dpy-30 homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 106 amino acids
Theoretical weight: 12.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9C005 (Residues: 1-99; Coverage: 100%)
Gene name: DPY30
Sequence domains: Dpy-30 motif
Structure domains: cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain

Ligands and Environments

1 bound ligand:
Ligand FMT 3 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P41212
Unit cell:
a: 89.579Å b: 89.579Å c: 53.202Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.207 0.235
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The complex activities of the SET1/MLL complex core subunits in development and disease.
Jiang H. (2020)
4 other articles