› 4rp7

X-ray diffraction
1.58Å resolution

Structure of the amyloid-forming segment TIITLE from p53 (residues 253-258)

Released:
DOI: 10.2210/pdb4rp7/pdb
PDB entry 4rp7 coloured by chain, front view.
PDB entry 4rp7 coloured by chain, side view.
PDB entry 4rp7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.
Soragni A, Janzen DM, Johnson LM, Lindgren AG, Thai-Quynh Nguyen A, Tiourin E, Soriaga AB, Lu J, Jiang L, Faull KF, Pellegrini M, Memarzadeh S, Eisenberg DS
Cancer Cell 29 90-103 (2016)
PMID: 26748848

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138139 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chain: Z
Molecule details ›
Chain: Z
Length: 6 amino acids
Theoretical weight: 689 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 253-258; Coverage: 2%)
Gene names: P53, TP53

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 43.018Å b: 4.849Å c: 19.774Å
α: 90° β: 92.12° γ: 90°
R-values:
R R work R free
0.167 0.164 0.192
Expression system: Not provided

Quick links

Citations

88 review citations

Putting p53 in Context.
Kastenhuber et al. (2017)
87 more

2 mentions without citation

A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas.
Soragni et al. (2016)
1 more