› 4rka

X-ray diffraction
2.71Å resolution

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347

Released:
DOI: 10.2210/pdb4rka/pdb
PDB entry 4rka coloured by chain, front view.
PDB entry 4rka coloured by chain, side view.
PDB entry 4rka coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhu L, Ren X, Zhu J, Li H

Function and Biology Details

Reaction catalysed: 
(S)-dihydroorotate + a quinone = orotate + a quinol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169672 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydroorotate dehydrogenase (quinone), mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 390 amino acids
Theoretical weight: 42.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02127 (Residues: 29-395; Coverage: 93%)
Gene name: DHODH
Sequence domains: Dihydroorotate dehydrogenase
Structure domains: Aldolase class I

Ligands and Environments


Cofactor: Ligand FMN 1 x FMN
3 bound ligands:
Ligand ORO 1 x ORO
Ligand SO4 6 x SO4
Ligand 3RY 1 x 3RY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3221
Unit cell:
a: 90.65Å b: 90.65Å c: 122.45Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.167 0.163 0.228
Expression system: Escherichia coli

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