› 4rhp

X-ray diffraction
2.39Å resolution

Crystal structure of human COQ9 in complex with a phospholipid, Northeast Structural Genomics Consortium Target HR5043

Released:
DOI: 10.2210/pdb4rhp/pdb
PDB entry 4rhp coloured by chain, front view.
PDB entry 4rhp coloured by chain, side view.
PDB entry 4rhp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis.
Lohman DC, Forouhar F, Beebe ET, Stefely MS, Minogue CE, Ulbrich A, Stefely JA, Sukumar S, Luna-Sánchez M, Jochem A, Lew S, Seetharaman J, Xiao R, Wang H, Westphall MS, Wrobel RL, Everett JK, Mitchell JC, López LC, Coon JJ, Tong L, Pagliarini DJ
Proc Natl Acad Sci U S A 111 E4697-705 (2014)
PMID: 25339443

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130883 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquinone biosynthesis protein COQ9, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 235 amino acids
Theoretical weight: 27.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75208 (Residues: 84-318; Coverage: 74%)
Gene names: C16orf49, COQ9, HSPC326, PSEC0129
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand PEF 1 x PEF
1 modified residue:
Ligand MSE 22 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 38.34Å b: 97.628Å c: 64.109Å
α: 90° β: 95.77° γ: 90°
R-values:
R R work R free
0.187 0.179 0.246

Quick links

Citations

21 review citations

Biosynthesis of coenzyme Q in eukaryotes.
Kawamukai M. (2016)
20 more

3 mentions without citation

Biochemistry of Mitochondrial Coenzyme Q Biosynthesis.
Stefely et al. (2017)
2 more