› 4rda

X-ray diffraction
2.5Å resolution

X-RAY STRUCTURE OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN IN COMPLEX WITH A HEPARIN DODECASACCHARIDE

Released:
DOI: 10.2210/pdb4rda/pdb
PDB entry 4rda coloured by chain, front view.
PDB entry 4rda coloured by chain, side view.
PDB entry 4rda coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
Dahms SO, Mayer MC, Roeser D, Multhaup G, Than ME
Acta Crystallogr D Biol Crystallogr 71 494-504 (2015)
PMID: 25760599

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156407 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Amyloid beta precursor like protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 24.46 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P51693 (Residues: 290-495; Coverage: 34%)
Gene name: APLP1
Sequence domains: E2 domain of amyloid precursor protein
Structure domains: Amyloid precursor protein, E2 domain

Ligands and Environments

Carbohydrate polymer : NEW Components: IDS, SGN, UAP
Carbohydrate polymer
Carbohydrate polymer : NEW Components: IDS, SGN
Carbohydrate polymer
1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P3121
Unit cell:
a: 91.969Å b: 91.969Å c: 208.481Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.216 0.245
Expression system: Komagataella pastoris

Quick links

Citations

3 review citations

Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease.
Habib et al. (2017)
2 more

1 mention without citation

Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.
Dahms et al. (2015)