› 4rah

X-ray diffraction
1.4Å resolution

Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.4 Angstrom resolution

Released:
DOI: 10.2210/pdb4rah/pdb
PDB entry 4rah coloured by chain, front view.
PDB entry 4rah coloured by chain, side view.
PDB entry 4rah coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A covalent homodimer probing early oligomers along amyloid aggregation.
Halabelian L, Relini A, Barbiroli A, Penco A, Bolognesi M, Ricagno S
Sci Rep 5 14651 (2015)
PMID: 26420657

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158376 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin Chain: A
Molecule details ›
Chain: A
Length: 100 amino acids
Theoretical weight: 11.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2221
Unit cell:
a: 32.349Å b: 47.704Å c: 119.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.166 0.209
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The Early Phase of β2-Microglobulin Aggregation: Perspectives From Molecular Simulations.
Loureiro et al. (2020)
9 other articles

1 mention without citation

A covalent homodimer probing early oligomers along amyloid aggregation.
Halabelian et al. (2015)