› 4qpp

X-ray diffraction
2.52Å resolution

The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound DS-421 (2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE

Released:
DOI: 10.2210/pdb4qpp/pdb
PDB entry 4qpp coloured by chain, front view.
PDB entry 4qpp coloured by chain, side view.
PDB entry 4qpp coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Zeng H, Smil D, Walker JR, He H, Eram M, Bountra C, Arrowsmith CH, Edwards AM, Vedadi M, Brown PJ, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165121 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein arginine N-methyltransferase 6 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 376 amino acids
Theoretical weight: 42.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96LA8 (Residues: 1-375; Coverage: 100%)
Gene names: HRMT1L6, PRMT6
Sequence domains: Methyltransferase domain
Structure domains:
POLY-UNK Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 7 amino acids
Theoretical weight: 614 Da
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda

Ligands and Environments

2 bound ligands:
Ligand SAH 3 x SAH
Ligand 36S 3 x 36S
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P4222
Unit cell:
a: 133.884Å b: 133.884Å c: 133.419Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.191 0.234
Expression system: Spodoptera frugiperda

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