› 4q2y

X-ray diffraction
2.8Å resolution

Crystal structure of Arginyl-tRNA synthetase

Released:
DOI: 10.2210/pdb4q2y/pdb
PDB entry 4q2y coloured by chain, front view.
PDB entry 4q2y coloured by chain, side view.
PDB entry 4q2y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of arginyl-tRNA synthetase from Homo sapiens.
Kim HS, Cha SY, Jo CH, Han A, Hwang KY
FEBS Lett 588 2328-34 (2014)
PMID: 24859084

Function and Biology Details

Reaction catalysed: 
ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginine--tRNA ligase, cytoplasmic Chains: A, B
Molecule details ›
Chains: A, B
Length: 607 amino acids
Theoretical weight: 69.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P54136 (Residues: 73-660; Coverage: 89%)
Gene names: RARS, RARS1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-1A
Spacegroup: P212121
Unit cell:
a: 77.623Å b: 105.234Å c: 172.259Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.208 0.268
Expression system: Escherichia coli

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Citations

1 review citation

Arginine-dependent immune responses.
Martí I Líndez et al. (2021)
5 other articles