› 4p5w

X-ray diffraction
2.4Å resolution

Structure of the N- and C-terminal domain fusion of the human mitochondrial aspartate/glutamate carrier Citrin in the calcium-bound state

Released:
DOI: 10.2210/pdb4p5w/pdb
PDB entry 4p5w coloured by chain, front view.
PDB entry 4p5w coloured by chain, side view.
PDB entry 4p5w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.
Thangaratnarajah C, Ruprecht JJ, Kunji ER
Nat Commun 5 5491 (2014)
PMID: 25410934

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193817 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 411 amino acids
Theoretical weight: 45.98 KDa
Source organism: Homo sapiens
Expression system: Lactococcus lactis subsp. cremoris NZ9000
UniProt:
  • Canonical: Q9UJS0 (Residues: 2-320, 339-675; Coverage: 57%)
Gene name: SLC25A13
Sequence domains: Mitochondrial carrier protein

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 68.149Å b: 106.167Å c: 117.888Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.227
Expression system: Lactococcus lactis subsp. cremoris NZ9000

Quick links

Citations

14 review citations

Regulation of Amino Acid Transport in Saccharomyces cerevisiae.
Bianchi et al. (2019)
13 more

5 mentions without citation

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism.
Ruprecht et al. (2020)
4 more