4p2y

X-ray diffraction
2.3Å resolution

Crystal structure of the human RAGE ectodomain (fragment VC1C2) in complex with mouse S100A6

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero octamer
hetero tetramer
PDBe Complex ID:
PDB-CPX-146841 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Advanced glycosylation end product-specific receptor Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 32.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15109 (Residues: 23-323; Coverage: 79%)
Gene names: AGER, RAGE
Sequence domains:
Structure domains: Immunoglobulins
Protein S100-A6 Chain: B
Molecule details ›
Chain: B
Length: 91 amino acids
Theoretical weight: 10.19 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P14069 (Residues: 1-89; Coverage: 100%)
Gene names: Cacy, S100a6
Sequence domains: S-100/ICaBP type calcium binding domain
Structure domains: EF-hand

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: I222
Unit cell:
a: 76.78Å b: 113.39Å c: 140.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.187 0.207
Expression systems:
  • Escherichia coli
  • Escherichia coli BL21(DE3)