Function and Biology Details
Reaction catalysed:
ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L-methionine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- S-adenosylmethionine synthetase superfamily
- S-adenosylmethionine synthetase
- S-adenosylmethionine synthetase, conserved site
- S-adenosylmethionine synthetase, C-terminal
- S-adenosylmethionine synthetase, central domain
- S-adenosylmethionine synthetase, N-terminal
- NAD(P)-binding domain superfamily
- RmlD-like substrate binding domain
1 more domain
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151918 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
S-adenosylmethionine synthase isoform type-2
Molecule details ›
Chains: A, B, C, D
Length: 395 amino acids
Theoretical weight: 43.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 395 amino acids
Theoretical weight: 43.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P31153 (Residues: 1-395; Coverage: 100%)
Sequence domains:
- S-adenosylmethionine synthetase, N-terminal domain
- S-adenosylmethionine synthetase, central domain
- S-adenosylmethionine synthetase, C-terminal domain
Methionine adenosyltransferase 2 subunit beta
Molecule details ›
Chains: E, F
Length: 323 amino acids
Theoretical weight: 36.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: RmlD substrate binding domain
Structure domains: NAD(P)-binding Rossmann-like Domain
Length: 323 amino acids
Theoretical weight: 36.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9NZL9 (Residues: 19-334; Coverage: 95%)
Sequence domains: RmlD substrate binding domain
Structure domains: NAD(P)-binding Rossmann-like Domain
