4n1s

X-ray diffraction
1.47Å resolution

Structure of Cyclophilin A in complex with benzohydrazide.

Released:
Source organism: Homo sapiens
Entry authors: Mcnae IW, Dornan J, Walkinshaw MD

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-158766 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase A Chain: A
Molecule details ›
Chain: A
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P212121
Unit cell:
a: 42.35Å b: 53.18Å c: 89Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.159 0.156 0.224
Expression system: Escherichia coli