› 4mpg

X-ray diffraction
1.95Å resolution

Crystal structure of human glutathione transferase theta-2, complex with glutathione and unknown ligand, target EFI-507257

Released:
DOI: 10.2210/pdb4mpg/pdb
PDB entry 4mpg coloured by chain, front view.
PDB entry 4mpg coloured by chain, side view.
PDB entry 4mpg coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Patskovsky Y, Toro R, Bhosle R, Hillerich B, Seidel RD, Washington E, Scott Glenn A, Chowdhury S, Evans B, Hammonds J, Imker HJ, Al Obaidi N, Stead M, Love J, Gerlt JA, Armstrong RN, Almo SC, Enzyme Function Initiative (EFI)

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase theta-2B Chains: A, B
Molecule details ›
Chains: A, B
Length: 266 amino acids
Theoretical weight: 30.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P0CG30 (Residues: 1-244; Coverage: 100%)
Gene names: GSTT2, GSTT2B
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 2 x GSH
2 bound ligands:
Ligand UNL 1 x UNL
Ligand FMT 1 x FMT
1 modified residue:
Ligand CSO 2 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P3121
Unit cell:
a: 93.55Å b: 93.55Å c: 119.073Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.171 0.17 0.22
Expression system: Escherichia coli BL21(DE3)

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