› 4lwd

X-ray diffraction
1.79Å resolution

Human CARMA1 CARD domain

Released:
DOI: 10.2210/pdb4lwd/pdb
PDB entry 4lwd coloured by chain, front view.
PDB entry 4lwd coloured by chain, side view.
PDB entry 4lwd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.
Qiao Q, Yang C, Zheng C, Fontán L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman EH, Wu H
Mol Cell 51 766-79 (2013)
PMID: 24074955

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-189792 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase recruitment domain-containing protein 11 Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 11.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BXL7 (Residues: 18-110; Coverage: 8%)
Gene names: CARD11, CARMA1
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas

Ligands and Environments

2 bound ligands:
Ligand SO4 3 x SO4
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P4132
Unit cell:
a: 82.045Å b: 82.045Å c: 82.045Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.199 0.223
Expression system: Escherichia coli

Quick links

Citations

41 review citations

The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules.
Wu et al. (2016)
40 more

5 mentions without citation

The CBM signalosome: potential therapeutic target for aggressive lymphoma?
Yang et al. (2014)
4 more