› 4l5b

X-ray diffraction
1.94Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + deoxyguanosine = ADP + dGMP
NTP + deoxycytidine = NDP + dCMP
ATP + deoxyadenosine = ADP + dAMP
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151058 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxycytidine kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 280 amino acids
Theoretical weight: 32.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P27707 (Residues: 1-260; Coverage: 100%)
Gene name: DCK
Sequence domains: Deoxynucleoside kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand 1UX 2 x 1UX
Ligand UDP 2 x UDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P41
Unit cell:
a: 68.671Å b: 68.671Å c: 120.019Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.233
Expression system: Escherichia coli BL21

Quick links

Citations

1 review citation

Radiopharmaceuticals as probes to characterize tumour tissue.
Alam et al. (2015)
13 other articles

2 mentions without citation

Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
Murphy et al. (2013)
1 more