› 4ksy

X-ray diffraction
1.88Å resolution

Crystal structure of STING in complex with cGAMP

Released:
DOI: 10.2210/pdb4ksy/pdb
PDB entry 4ksy coloured by chain, front view.
PDB entry 4ksy coloured by chain, side view.
PDB entry 4ksy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING.
Zhang X, Shi H, Wu J, Zhang X, Sun L, Chen C, Chen ZJ
Mol Cell 51 226-35 (2013)
PMID: 23747010

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 27.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 138-379; Coverage: 64%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 1SY 1 x 1SY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 89.522Å b: 77.927Å c: 35.974Å
α: 90° β: 96.97° γ: 90°
R-values:
R R work R free
0.163 0.161 0.182
Expression system: Escherichia coli

Quick links

Citations

193 review citations

Interferon-stimulated genes: a complex web of host defenses.
Schneider et al. (2014)
192 more

34 mentions without citation

The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
Decout et al. (2021)
33 more