› 4k7q

X-ray diffraction
3.5Å resolution

Crystal Structure of AcrB Complexed with Linezolid at 3.5 Resolution

Released:
DOI: 10.2210/pdb4k7q/pdb
PDB entry 4k7q coloured by chain, front view.
PDB entry 4k7q coloured by chain, side view.
PDB entry 4k7q coloured by chain, top view.
Source organism: Escherichia coli K-12
Primary publication:
Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution.
Hung LW, Kim HB, Murakami S, Gupta G, Kim CY, Terwilliger TC
J Struct Funct Genomics 14 71-5 (2013)
PMID: 23673416

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151927 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Multidrug efflux pump subunit AcrB Chain: A
Molecule details ›
Chain: A
Length: 1053 amino acids
Theoretical weight: 114.22 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P31224 (Residues: 1-1049; Coverage: 100%)
Gene names: JW0451, acrB, acrE, b0462
Sequence domains: AcrB/AcrD/AcrF family
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZLD 1 x ZLD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: R32
Unit cell:
a: 144.685Å b: 144.685Å c: 519.357Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 0.251 0.304
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Molecular mechanisms of antibiotic resistance.
Blair et al. (2015)
9 more

4 mentions without citation

Structural Insights into Transporter-Mediated Drug Resistance in Infectious Diseases.
Kim et al. (2021)
3 more