› 4k0d

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-173649 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
histidine kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 152 amino acids
Theoretical weight: 15.73 KDa
Source organism: Anaeromyxobacter dehalogenans 2CP-C
Expression system: Escherichia coli
UniProt:
  • Canonical: Q2IDQ5 (Residues: 33-184; Coverage: 22%)
Gene name: Adeh_2942
Structure domains: Four Helix Bundle (Hemerythrin (Met), subunit A)

Ligands and Environments

4 bound ligands:
Ligand ZN 5 x ZN
Ligand CL 4 x CL
Ligand NA 1 x NA
Ligand ACT 2 x ACT
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2
Unit cell:
a: 87.693Å b: 75.184Å c: 51.031Å
α: 90° β: 105.18° γ: 90°
R-values:
R R work R free
0.201 0.198 0.252
Expression system: Escherichia coli

Quick links

Citations

5 citation in other articles

Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae.
Brewster et al. (2016)
4 more

3 mentions without citation

Diversity in Sensing and Signaling of Bacterial Sensor Histidine Kinases.
Ishii et al. (2021)
2 more