› 4jcd

X-ray diffraction
2Å resolution

S268Y Variant of JC Polyomavirus Major Capsid Protein VP1

Released:
DOI: 10.2210/pdb4jcd/pdb
PDB entry 4jcd coloured by chain, front view.
PDB entry 4jcd coloured by chain, side view.
PDB entry 4jcd coloured by chain, top view.
Source organism: JC polyomavirus
Primary publication:
Progressive multifocal leukoencephalopathy-associated mutations in the JC polyomavirus capsid disrupt lactoseries tetrasaccharide c binding.
Maginnis MS, Ströh LJ, Gee GV, O'Hara BA, Derdowski A, Stehle T, Atwood WJ
mBio 4 e00247-13 (2013)
PMID: 23760462

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136562 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major capsid protein VP1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 272 amino acids
Theoretical weight: 30.15 KDa
Source organism: JC polyomavirus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03089 (Residues: 23-290; Coverage: 76%)
Sequence domains: Polyomavirus coat protein
Structure domains: Capsid protein VP1,Polyomavirus

Ligands and Environments

2 bound ligands:
Ligand GOL 5 x GOL
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 150.15Å b: 96.18Å c: 128.36Å
α: 90° β: 110.39° γ: 90°
R-values:
R R work R free
0.166 0.164 0.204
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

Virus-Receptor Interactions: The Key to Cellular Invasion.
Maginnis MS. (2018)
11 more

1 mention without citation

Progressive multifocal leukoencephalopathy-associated mutations in the JC polyomavirus capsid disrupt lactoseries tetrasaccharide c binding.
Maginnis et al. (2013)