Function and Biology Details
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Mitogen-activated protein (MAP) kinase, ERK1/2
- Death effector domain
- Death-like domain superfamily
- Astrocytic phosphoprotein PEA-15, death effector domain
- Serine/threonine-protein kinase, active site
- Mitogen-activated protein (MAP) kinase, conserved site
- Protein kinase, ATP binding site
- Protein kinase domain
1 more domain
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151236 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mitogen-activated protein kinase 1
Molecule details ›
Chains: A, B, C, D
Length: 356 amino acids
Theoretical weight: 41.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Protein kinase domain
Structure domains:
Length: 356 amino acids
Theoretical weight: 41.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P28482 (Residues: 8-360; Coverage: 98%)
Sequence domains: Protein kinase domain
Structure domains:
Astrocytic phosphoprotein PEA-15
Molecule details ›
Chains: E, F, G, H
Length: 133 amino acids
Theoretical weight: 15.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Death effector domain
Structure domains: Death Domain, Fas
Length: 133 amino acids
Theoretical weight: 15.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q15121 (Residues: 1-130; Coverage: 100%)
Sequence domains: Death effector domain
Structure domains: Death Domain, Fas
