› 4hzs

X-ray diffraction
3.23Å resolution

Crystal structure of Ack1 kinase domain with C-terminal SH3 domain

Released:
DOI: 10.2210/pdb4hzs/pdb
PDB entry 4hzs coloured by chain, front view.
PDB entry 4hzs coloured by chain, side view.
PDB entry 4hzs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ack1: activation and regulation by allostery.
Gajiwala KS, Maegley K, Ferre R, He YA, Yu X
PLoS One 8 e53994 (2013)
PMID: 23342057

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activated CDC42 kinase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 341 amino acids
Theoretical weight: 38.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q07912 (Residues: 115-453; Coverage: 33%)
Gene names: ACK1, TNK2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P4
Unit cell:
a: 145.463Å b: 145.463Å c: 103.745Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.246 0.27
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
Mahajan et al. (2015)
3 more

6 mentions without citation

ACKnowledging the role of the Activated-Cdc42 associated kinase (ACK) in regulating protein stability in cancer.
Hodder et al. (2023)
5 more