4hkr

X-ray diffraction
3.35Å resolution

Calcium release-activated calcium (CRAC) channel ORAI

Released:
Source organism: Drosophila melanogaster
Primary publication:
Crystal structure of the calcium release-activated calcium channel Orai.
Science 338 1308-13 (2012)
PMID: 23180775

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
PDBe Complex ID:
PDB-CPX-193611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium release-activated calcium channel protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 214 amino acids
Theoretical weight: 24.35 KDa
Source organism: Drosophila melanogaster
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9U6B8 (Residues: 133-341; Coverage: 60%)
Gene names: CG11430, CRACM1, Orai, olf186-F
Sequence domains: Mediator of CRAC channel activity
Structure domains: Calcium release-activated calcium channel protein Orai

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P213
Unit cell:
a: 117.91Å b: 117.91Å c: 117.91Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.278 0.278 0.279
Expression system: Komagataella pastoris