4h25

X-ray diffraction
2.2Å resolution

TCR interaction with peptide mimics of nickel offers structure insights to nickel contact allergy

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-110783 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
HLA class II histocompatibility antigen, DR alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 180 amino acids
Theoretical weight: 20.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01903 (Residues: 28-207; Coverage: 79%)
Gene names: HLA-DRA, HLA-DRA1
Sequence domains:
Structure domains:
Ig-like domain-containing protein Chains: B, E
Molecule details ›
Chains: B, E
Length: 188 amino acids
Theoretical weight: 21.94 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: B8YAC7 (Residues: 1-183; Coverage: 100%)
Gene name: HLA-DRB3
Sequence domains:
Structure domains:
peptide Chains: C, F
Molecule details ›
Chains: C, F
Length: 22 amino acids
Theoretical weight: 2.49 KDa

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: C2
Unit cell:
a: 154.52Å b: 97.18Å c: 67.1Å
α: 90° β: 105.36° γ: 90°
R-values:
R R work R free
0.22 0.21 0.255
Expression system: Homo sapiens