› 4g42

X-ray diffraction
2.29Å resolution

Structure of the Chicken MHC Class I Molecule BF2*0401 complexed to pepitde P8D

Released:
DOI: 10.2210/pdb4g42/pdb
PDB entry 4g42 coloured by chain, front view.
PDB entry 4g42 coloured by chain, side view.
PDB entry 4g42 coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Narrow groove and restricted anchors of MHC class I molecule BF2*0401 plus peptide transporter restriction can explain disease susceptibility of B4 chickens.
Zhang J, Chen Y, Qi J, Gao F, Liu Y, Liu J, Zhou X, Kaufman J, Xia C, Gao GF
J Immunol 189 4478-87 (2012)
PMID: 23041567

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-129229 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chains: A, D
Molecule details ›
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: O46790 (Residues: 22-291; Coverage: 81%)
Gene names: B-FIV, BF2
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 101 amino acids
Theoretical weight: 11.47 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli
UniProt:
  • Canonical: P21611 (Residues: 22-119; Coverage: 100%)
Gene name: B2M
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
FUS/TLS Chains: C, F
Molecule details ›
Chains: C, F
Length: 8 amino acids
Theoretical weight: 996 Da
Source organism: Gallus gallus
Expression system: Not provided
UniProt:
  • Canonical: Q6J4Y8 (Residues: 319-326; Coverage: 2%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: C2
Unit cell:
a: 165.832Å b: 40.108Å c: 130.952Å
α: 90° β: 119.56° γ: 90°
R-values:
R R work R free
0.254 0.196 0.254
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

6 review citations

Brief review of the chicken Major Histocompatibility Complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance.
Miller et al. (2016)
5 more

2 mentions without citation

Narrow groove and restricted anchors of MHC class I molecule BF2*0401 plus peptide transporter restriction can explain disease susceptibility of B4 chickens.
Zhang et al. (2012)
1 more