› 4g34

X-ray diffraction
2.7Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192755 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 2-alpha kinase 3 Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZJ5 (Residues: 588-1093; Coverage: 27%)
Gene names: EIF2AK3, PEK, PERK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 924 1 x 924
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P6122
Unit cell:
a: 101.46Å b: 101.46Å c: 158.312Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.208 0.258
Expression system: Escherichia coli

Quick links

Citations

113 review citations

The integrated stress response.
Pakos-Zebrucka et al. (2016)
112 more

2 mentions without citation

A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models.
Ganz et al. (2020)
1 more