› 4fq3

X-ray diffraction
3Å resolution

Crystal structure of transportin/FUS-NLS

Released:
DOI: 10.2210/pdb4fq3/pdb
PDB entry 4fq3 coloured by chain, front view.
PDB entry 4fq3 coloured by chain, side view.
PDB entry 4fq3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gong W, Niu C, Jia M, Gao F

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152978 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transportin-1 Chain: A
Molecule details ›
Chain: A
Length: 890 amino acids
Theoretical weight: 101.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q92973 (Residues: 9-898; Coverage: 99%)
Gene names: KPNB2, MIP1, TNPO1, TRN
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
RNA-binding protein FUS Chain: B
Molecule details ›
Chain: B
Length: 37 amino acids
Theoretical weight: 3.98 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P35637 (Residues: 493-526; Coverage: 7%)
Gene names: FUS, TLS

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21212
Unit cell:
a: 128.811Å b: 158.292Å c: 68.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.198 0.251

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