› 4evh

X-ray diffraction
2.6Å resolution

Crystal structure of calcium-bound alpha-1 giardin

Released:
DOI: 10.2210/pdb4evh/pdb
PDB entry 4evh coloured by chain, front view.
PDB entry 4evh coloured by chain, side view.
PDB entry 4evh coloured by chain, top view.
Source organism: Giardia intestinalis
Primary publication:
Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms.
Weeratunga SK, Osman A, Hu NJ, Wang CK, Mason L, Svärd S, Hope G, Jones MK, Hofmann A
J Mol Biol 423 169-81 (2012)
PMID: 22796298

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147861 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Giardin subunit alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 33.94 KDa
Source organism: Giardia intestinalis
Expression system: Escherichia coli
UniProt:
  • Canonical: P17063 (Residues: 1-295; Coverage: 100%)
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 51.309Å b: 58.363Å c: 98.762Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.213 0.304
Expression system: Escherichia coli

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Citations

1 review citation

Structure-function analysis of apical membrane-associated molecules of the tegument of schistosome parasites of humans: prospects for identification of novel targets for parasite control.
Leow et al. (2015)
10 other articles