› 4etv

X-ray diffraction
1.65Å resolution

Crystal structure of mouse ryanodine receptor 2 (2699-2904)

Released:
DOI: 10.2210/pdb4etv/pdb
PDB entry 4etv coloured by chain, front view.
PDB entry 4etv coloured by chain, side view.
PDB entry 4etv coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain.
Yuchi Z, Lau K, Van Petegem F
Structure 20 1201-11 (2012)
PMID: 22705209

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-123214 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 24.63 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: E9Q401 (Residues: 2699-2904; Coverage: 4%)
Gene name: Ryr2
Sequence domains: RyR domain
Structure domains: Globin-like

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
1 modified residue:
Ligand MSE 16 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 58.9Å b: 88.22Å c: 92.07Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.228 0.25
Expression system: Escherichia coli

Quick links

Citations

28 review citations

Ryanodine receptors: structure and function.
Van Petegem F. (2012)
27 more

4 mentions without citation

Structural Insight Into Ryanodine Receptor Channelopathies.
Hadiatullah et al. (2022)
3 more